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French Neglected Tropical Diseases Research Group

Finding sustainable solutions to fight NTDs

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Operational research on filariasis and soil-transmitted helminths

  • Research on filariasis has brought major results, in particular the first demonstration that lymphatic filariasis can be eliminated by twice-yearly mass treatments with albendazole alone. This strategy is now recommended by WHO in areas where LF is coendemic with loaisis and where the classical combination of ivermectin+albendazole cannot be used because of the risk of post-ivermectin encephalopathy.

  • In addition, the group demonstrated, for the first time, the efficacy and applicability of a rapid Loa Loa microfilaremia quantification tool (the LoaScope®) to identify subjects at risk for developing post-ivermectin encephalopathy. Also for the first time, the group demonstrated that excess mortality was associated with high Loa Loa microfilaremia.

  • Finally, also for the first time, it was shown that high Onchocerca volvulus microfilaremia in childhood is associated with the risk of developing epilepsy.

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